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Principal Scientist, Assay Development

CK GROUP
Job LocationCambridge
EducationNot Mentioned
SalarySalary negotiable
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent , full-time

Job Description

CK Group are recruiting for a Principal Scientist, Assay Development on behalf of a growing biotechnology company creating novel therapies for use in oncology and other diseases. This is to be based at their site in Cambridge on a permanent basis.This exciting role is at the core of our clients ongoing target validation and drug discovery programmes, covering projects from hit identification to candidate selection and beyond. The successful candidate will be primarily lab based and will use their scientificcreativity and innovation to design and develop novel biochemical and cell-based assays. They will work closely with internal colleagues and collaboration partners to build and run assay screening cascades and analyse data to support and progress the smallmolecule drug discovery projects. The key responsibilities will be to:

  • Innovate, design and develop bespoke cell-based assays across a range of technologies (eg reporter gene assays, CRISPR, proliferation assays etc) to assess target validation, compound mechanism of action, cellular target engagement and downstream effects
  • Be primarily responsible for vector design and vector generation for a range of applications
  • Develop plate-based biochemical/biophysical assays (eg enzyme assays, ELISA, SPR etc)
  • Analyse and share critical interpretation of experimental results to include troubleshooting and next step proposals
  • Line management of research scientist
To be considered for the position you should have the following:
  • BSc or equivalent in Biology, Biochemistry or another relevant Biological Science discipline
  • 5 years post-PhD or equivalent relevant laboratory experience, with strong demonstrated ability in molecular biology, cell line generation and assay development/screening
  • Experience of a wide range of assay technologies and high throughput lab equipment eg plate readers, compound handling robotics
  • Experience in working with RNA
  • Prior experience of line managing/mentoring more junior lab scientists
  • Ability to work in a dynamic and collaborative small biotech environment, independently and as part a multidisciplinary team. Experience working with CROs and/or academic or industry partnerships desirable
Apply:It is essential that applicants hold entitlement to work in the UK. Please quote job reference 55710 in all correspondence.

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