DMPK Group Leader

Job Description

DMPK Group LeaderUp to £76,000 depending on experiencePermanentCambridgeCpl Life Sciences have partnered with a leading and highly regarded charity organization in the UK to recruit for a DMPK Group Leader.Key Responsibilities:• Design, propose and execute innovative experiments which positively impact projects and the overall direction of in vitro/in vivo science.• Maintain awareness of external developments in the DMPK and PKPD fields, the application of these to on-going projects and proactively suggest and evaluate new techniques.• Contribute to the strategic leadership within the Medicinal Chemistry and DMPK group, as well as the overall Therapeutic Innovation research strategy.• Effectively manage appropriate outsourcing activities.• Effectively prioritise and co-ordinates multiple areas of work.• Lead and drive a high-performing team to provide all aspects of DMPK and PKPD expertise.• Manage internal expertise, capacity, and resources to drive governance and decision-making regarding scientific portfolio support and technology development.• Present and clarify results across departments and to alliance partners.• Be a recognised and passionate leader, able to represent the department across a broad range of therapeutic projects and cross-site initiatives, both internally as well as externally.• Drive scientific and technical innovation, including through external collaboration and partnership.Skills required:• PhD or equivalent experience in Pharmaceutics, Pharmacology, Drug metabolism or Pharmacokinetics encompassing a significant element of Modelling & Simulation, such as quantitative pharmacology, systems biology, pharmacometrics, applied mathematics.• Significant experience and deep expertise in DMPK aspects of drug discovery.• Relevant industry experience in Modelling & Simulation in a preclinical and translational setting.• Proven track record of delivering PK, PKPD and TKPD aspects to projects, including significant experience in translating drug-target kinetics through to mechanistic PKPD modelling for therapeutic dose prediction.• Expert in specialist tools such as MATLAB, SimCYP, WinNonLin/Phoenix NLME.• Proven track record of portfolio impact across a range of challenging target classes, through intellectual and laboratory-based contributions, and project leadership.• Strong external reputation in translational PKPD modelling and DMPK, evidenced through wide personal network, external presentation, and publication in high-impact journals.• Track record of delivering results across a diverse project portfolio by driving strategic and scientific initiatives.• Deep expertise in translational PKPD modelling and DMPK.• Confidence and credibility to work at the intersection between mechanistic pharmacology, medicinal chemistry, computational chemistry & DMPK to define and prosecute strategies that deliver impactful insight across a range of challenging target classes,through to clinical dose prediction.• Excellent communication skills, ability to influence multiple stakeholders and collaborate across projects and sites.• A passion for promotion of scientific excellence, through external publication, presentations etc.• Excellent team-working skills combined with cross-functional knowledgeIf you are interested in this fantastic and unique opportunity, please send your CV to