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Principal Scientist Target Validation & Disease Biology

ADLIB
Job LocationLondon
EducationNot Mentioned
SalaryCompetitive salary
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

  • Fast growing and extremely innovative scale-up
  • Utilising unique methods for drug discovery
  • Strong career progression opportunities
    • This is an opportunity to join an exciting drug discovery innovator utilising machine learning to vastly improve the drug discovery process and produce more effective therapeutics worldwide. In line with growth, they are searching for an experienced Principal Scientist with strong Target Validation & Disease Biology to play a leading role to influence the direction of novel protein-based therapeutics.What you’ll be doing:You will be the lead scientist for target identification/validation activities in the company and will play a leading role in shaping their understanding of key disease biology questions relating to their asset programs. You will have primary responsibility for evaluating target opportunities across multiple disease areas. By mining multiple sources of data and leading focussed lab-based investigation you will assess the biological feasibility of novel targets. You will work closely with the commercial team, asset leads, and platform leads to prioritise early targets in the context of unmet need, commercial value, and the technical fit with their discovery platform. Your disease biology expertise will play a crucial role in shaping the portfolio of novel protein-based therapeutics and your work will ultimately support preclinical, biomarker and patient stratification strategies.What you’ll do in this role
  • Lead lines of investigation to support early target discovery and to propose targets for novel biologics-based asset development programs.
  • Evaluate new focus areas for Machine Learning-led discovery in the context of biological and competitive impact
  • Develop and/or access innovative disease area models and systems to test therapeutic approaches to cancer, autoimmune and other immunological disorders.
  • Provide direct line and/or matrix management for multi-disciplinary teams of scientists. You will be comfortable providing mentorship for others, supporting them in goal setting and helping them to achieve their scientific and career aspirations.
  • You will be expected to propose and manage collaborations with both internal and external experts to further our research and enhance our capabilities.
  • You will contribute data to and assist in the preparation of target nomination packages, partnering and investor materials, oral presentations, IND documents and manuscripts for publications.
    • What you’ll need to applyIn this role you will be expected to work independently as well as part of the team. You will feel confident in being recognised as a disease biology expert and to give opinions that influence the overall direction of our research programmes. You will be a key member of the pipeline strategy team and will be comfortable and articulate in disseminating information and communicating across all disciplines for the furthering of the company’s research goals.Experience and knowledge Essential
  • BSc, MSc and/or PhD or equivalent in a life sciences discipline.
  • Strong cellular and molecular biology skills.
  • Post-graduate experience in Oncology, Autoimmune and/or Immunology, preferably within an industrial setting and with a track record of research achievement.
  • Experience of mentoring of other scientists to achieve greater success in their project objectives.
  • Ability to evaluate information from multiple diverse sources or disciplines to drive hypothesis-driven research.
  • Excellent written and oral communication skills.
    • Desirable
  • Direct line management, mentoring, performance management and development.
  • Previous experience of project leadership in a pharma or biotech environment.
  • To have worked on projects that include in vivo and/or human tissue data.
  • Previous experience of working with transcriptomics and/or genomics data.
  • Experience working with computational scientists, bioinformaticians, systems biology or synthetic biology.
    • What you’ll get in return for your experienceTo be part of a brilliant and purpose driven team, for a company dedicated to have a positive impact on human health, with like minded people. The company also offers flexible working, self-study budgets, one to one coaching, and they are big on diversity!Whats nextFor more information or to apply, apply directly to this advert to speak with Roy Bennett

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