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Principal Scientist (Upstream)

Job LocationDarlington
EducationNot Mentioned
Salary£36,000 - £45,000 per annum
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Imperial Professionals are delighted to announce that we are working with a ground-breaking innovative pharmaceutical manufacturer to appoint a Principal Scientist (Downstream).A dynamic global company their focus is to combine technical leadership in cell culture, microbial fermentation and gene therapies with world class cGMP manufacturing facilities to advance tomorrow’s medicines.LOCATION: DarlingtonSALARY: Up to £45,000SHIFT/WORKING HOURS: 40 hours week (Mon-Fri)ROLE SUMMARY:The Principal Scientist will act as the downstream lead (responsible for the delivery of the Downstream elements; Clarification (depth filtration/centrifugation), chromatography, UFDF, Final filtration) for customer programs. The successful candidate will be responsible for managing a small team of junior scientists to ensure the successful delivery of the Downstream portion of customer programs. The role is a highly technical role that will also involve interactions with both customers and internal stakeholders. The role will also encompass involvement in GMP operations up to 200L scale. Ideally the candidate will have experience of working with Viral Vectors (AAV, Lenti, or Adenovirus) or viral vaccines, although this is not a pre-requisite.ESSENTIAL REQUIREMENTS:

  • Line management experience
  • Practical and theoretical expertise in mammalian cell culture - suspension
  • Expertise of how to scale up cell culture processes
  • Proficiency in running stirred tank bioreactors
  • Good presentation, and organizational skills
  • Some industrial (non academic) experience
  • They need to be able to develop a cell culture process so it is scalable and repeatable with minimal supervision and support
  • Ability to plan and deliver projects to agreed timelines.
  • Good communication skills.
  • Willingness to learn new technologies and scientific concepts
  • DESIRABLE REQUIREMENTS:
  • Experience of working with gene therapy vectors; AAV, Adenovirus and/or Lentivirus
  • Adherent cell culture experience
  • Experience of performing Transfections/infections of mammalian cell cultures
  • Experience of working with HEK293, SF9, HEK293-T
  • Prior CDMO experience
  • Proficiency in the use of the Cytiva XDR platform
  • Understanding of cGMP
  • Experience of chemical cell lysis and enzymatic DNA removal.
  • For more information on this opportunity please feel free to contact Adam Pearson at Imperial Professionals.

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