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Senior Director Oncology Translational Science

CK GROUP
Job LocationCambridge
EducationNot Mentioned
SalarySalary negotiable
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent , full-time

Job Description

Jim Gleeson is recruiting for a Senior Director Oncology Translational Science to join an innovative and exciting, clinical stage biotechnology company. They are based near to Cambridge and some home-working will be possible.Competitive salaryRESPONSIBILITIES:As Senior Director Oncology Translational Science you will play a key role in taking target validation/mechanistic biology through into appropriate translational model systems and into defined patient populations to support early clinical PoC. You will alsoprovide project leadership to key oncology asset(s) and oncology translational function expansion, leaning on utilizing their translational networks and strong interaction with Biomarkers, Bioinformatics and Clinical Development functions.Key duties will include:

  • Leading oncology projects from lead optimization through candidate selection and into early clinical development
  • Building an oncology translational science team to design and operationalize oncology translational strategies
  • Using translational oncology expertise to build upon target validation biology and progress DUB targets towards clinical evaluation in defined patient populations
  • Identifying and selecting target/mechanism appropriate in vivo models which support patient populations of interest.
  • Driving oncology biomarker function and patient stratification marker development
  • Developing and implementing research and clinical-level assays, along with data analysis, interpretation, and report generation
  • Working closely with the research team to identify novel biomarkers
  • Managing CROs responsible for the generation of in vivo preclinical oncology data and exploratory/development biomarker data
  • Transitioning research assays to LDTs and contribute to CDx development
  • Contributing to clinical documents such as, INDs, IBs, regulatory submissions, laboratory manuals and clinical protocols
QUALIFICATIONS:As Senior Director Oncology Translational Science you will require:
  • PhD in cancer biology, immunology, genomics, biochemistry or molecular/cellular biology
  • Extensive pharmaceutical or biotechnology industry experience in oncology or cancer immunotherapy (including DDR) with an emphasis on translational research and clinical biomarkers
  • Established network of KOLs to support oncology programs
  • Proven track record of transitioning oncology biomarkers from the bench to the clinic
  • Significant oncology publication record, including mechanisms and biomarkers
  • Significant experience with key oncology CROs for preclinical models and patient ID biomarker development
  • Experience with DDR, oncogenic driver genes/mutations, Wnt signalling pathways is preferred
  • Excellent communication skills and the ability present results in a clear and concise manner
  • Excellent interpersonal skills, personal integrity, professional manner and ability to gain respect and develop good working relationships with cross functional personnel at all levels
Apply:Please quote reference 52460 in all correspondence.

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