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Scientist Protein Characterisation

AstraZeneca
Job LocationCambridge
EducationNot Mentioned
SalaryCompetitive salary
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Scientist – Protein CharacterisationCambridgeSalary CompetitiveAt AstraZeneca, innovation is more than just research. As one of the worlds leading pharmaceutical companies, we’re passionate about providing innovative, effective medicines that make a real difference in areas of healthcare.We’re investing heavily into a research centre and headquarters at the Cambridge Biomedical Campus, and we seek to bring together the finest talent from industry and academia. Join us, and you’ll be part of an exciting vision for our industry, making a difference world-wide!Analytical Sciences operates in a highly cross-disciplinary environment and plays a crucial role in advancing new biopharmaceutical drug projects through the clinic. Central to our work is the detailed characterisation of our protein therapeutics, achieved principally through mass spectrometry and biophysical analysis.We are seeking a highly motivated Senior Scientist to join our Analytical Sciences group here at AstraZeneca on a permanent basis! Role Responsibilities

  • Predominantly laboratory-based position supporting the characterization of a broad portfolio of biologics, including mAbs, ADCs, bispecifics, enzymes, mRNA and viruses
  • Design and execute studies to understand the structure/function relationships in protein therapeutics.
  • Monitor critical quality attributes in support of upstream, downstream and formulation development
  • Method development, qualification, tech transfer and continuous improvement of physicochemical and/or characterization methods.
  • Analysis, interpretation and presentation of data to cross functional teams. Preparation of SOPs and technical reports.
  • Explore new technology and/or approaches to understand product variants and novel scaffolds
  • Represent the analytical function at research and CMC interfaces to support candidate drug selection, process development or clinical supply at SME level
    • Essential Requirements:
  • BSc, MSc, or PhD of relevant experience in biochemistry, chemistry or biotechnology with a strong understanding of protein chemistry
  • Extensive experience using LC-MS to characterise sequence variants, post-translational modification analysis and chemical modifications of biologics.
  • Confident developing molecule specific mass spectrometry methods and evaluating new technologies.
  • Experience of Biopharmaceutical Development and CMC related activities including supporting/authoring regulatory filings
  • High quality reporting/presentation of analytical data to audiences at all levels
  • Excellent track record of publications and/or conference presentations
  • Collaborate positively with colleagues in a forward thinking and cross-disciplinary/cross-functional environment
    • Desirable Requirements:
  • Practical experience analysing proteins/nucleic acid/nano particles/virus capsids using a number of biophysical techniques, such as CD, DSC, AUC, light scattering, infrared spectroscopy, light obscuration, and flow microscopy.
  • Familiarity with structural MS (HDX-MS, Native-MS and XL-MS, FPOP)
  • Familiarity with physicochemical methods such as N-linked glycan analysis, chromatography (SEC,IEC, RP), electrophoresis (SDS-PAGE and c-IEF) to analyse therapeutic proteins
  • Familiarity of carbohydrate biochemistry, and experience of techniques for characterising and quantifying glycan structures
    • Open Date 15/05/2020Close Date 15/06/2020AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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