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Scientist Mass Spectometry / Quantitative Proteomics

AstraZeneca
Job LocationCambridge
EducationNot Mentioned
SalaryCompetitive salary
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Scientist – Mass Spectrometry / Quantitative Proteomics CambridgeSalary & Benefits CompetitiveAt AstraZeneca every one of our employees makes a difference to patients lives every day.Innovation is more than just research. As one of the worlds leading pharmaceutical companies, we’re passionate about providing innovative and effective medicines that make a real difference in areas of healthcare.We’re investing heavily into a research Centre and headquarters at the Cambridge Biomedical Campus, we seek to bring together the finest talent from industry and academia. Join us, and you’ll be part of an exciting vision for our industry, making a difference world-wide!Analytical Sciences operates in a highly cross-disciplinary environment and plays a crucial role in advancing new biopharmaceutical drug projects through the clinic. Central to our work is the detailed characterisation of protein therapeutics and manufacturing processes, achieved principally through a combination of mass spectrometry, biophysical and physicochemical analyses.We are seeking a highly motivated Scientist to join our Analytical Sciences group here at AstraZeneca on a permanent basis! Main Duties and Responsibilities

  • Laboratory-based position supporting the characterization of a broad portfolio, including mAbs, ADCs, Bispecifics, enzymes, mRNA and viruses
  • Analysis using LC-MS to monitor post-translational modifications or chemical modifications in support of upstream, downstream and formulation development
  • Analysis of sophisticated biological matrices using sensitive and robust quantitative proteomics methods/workflows
  • Method development and continuous improvement of characterization and/or physicochemical methods
  • Analysis, interpretation, write-up and presentation of data to analytical colleagues
  • Preparation of SOPs and technical reports
    • What we need from you:
  • BSc or MSc experience in biochemistry, chemistry or biotechnology (or related field)
  • Proven experience in analysing proteins using mass spectrometry-based techniques, including experience with proteomics workflows and data analysis
  • Successfully developed and evaluated analytical methods and implemented innovative technologies
  • High attention to detail and excellent quality in reporting/presentation of analytical data
  • Working effectively in a dynamic, forward thinking and cross-disciplinary/cross functional environment
    • Desirable Knowledge/Experience:
  • Hands on MS-based proteomic experience is expected whilst familiarity with mRNA and viruses (AAV) is desirable but not essential
  • Experience or familiarity with biophysical techniques (CD, DSC, AUC, light scattering) to characterize primary, secondary and tertiary protein structure
  • Track record of scientific excellence in terms of publications and/or conference presentations
  • Experience working with HPLC (reversed phase, ion exchange, affinity and size exclusion), electrophoresis, qPCR and ELISA
  • Experience of Bioprocess Development and CMC related activities including experience supporting regulatory filings
    • Open Date 23/04/2020Close Date 29/05/2020AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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