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Scientist and Senior Sc Antibody Discovery and Characterisation

Job LocationCambridge
EducationNot Mentioned
SalarySalary negotiable
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Researching for the expression, purification and characterisation of a number of misfolding-related proteins and peptides utilising both the companys proprietary antibody platform and commercial antibodies. Advance the internal research programmes around innovative assay development for toxic oligomer measurements in protein misfolding diseases.Client DetailsMy client is a spin-off company from 2 leading universities focussing on protein misfolding diseases. They are pioneering an entirely new approach based on decades of research focused on the chemical kinetics of the protein misfolding process. They are on a mission to eliminate protein misfolding diseases, improving the lives of countless patients globally suffering from these debilitating and increasingly common medical disorders.Description

  • Develop antibody-based assays for the direct measurement of protein oligomeric toxic species
  • Design and carry out experiments and develop other biochemical and biophysical assays to quantify protein oligomers
  • Develop ELISA and SIMOA-based assays for assessing protein oligomer levels
  • Present data at cross-functional meetings and external conferences
  • Write and contribute to publications or disseminate research findings
  • Mentor and coach colleagues with less experience
  • Profile
  • A PhD or extensive experience working in a related discipline
  • Extensive experience in ELISA and other antibody-based binding/diagnostic assays
  • Previous knowledge in studying protein aggregation and misfolding is highly valuable
  • Experience in the recombinant expression and purification of proteins using chromatography techniques and their further characterisation using biochemical and biophysical techniques is a plus
  • The ability to work independently and lead, organise and participate in collaborative research projects
  • Excellent communication and teamwork skills is essential for working in highly multidisciplinary environments
  • Ability to handle effectively multiple projects and responsibilities
  • Experience in assisting to run a busy biophysical, biochemical or molecular biology laboratory
  • Job OfferThe opportunity to work for a growing and successful business in the Biotech industry, a generous salary, and benefits package. If you meet the above criteria and would be interested in working for us, then please apply.

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