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Job Location | Cambridge |
Education | Not Mentioned |
Salary | Competitive salary |
Industry | Not Mentioned |
Functional Area | Not Mentioned |
Job Type | Permanent, full-time |
Postdoctoral Fellow - B-Cell Signatures of High-Affinity AntibodiesLocation: Cambridge, UKSalary: Competitive on offerWe’re currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Cambridge, UK, you’ll be in a global pharmaceutical environment, contributing to live projects right from the start. You’ll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.About the Opportunity:Do you want to play a key role furthering important scientific research at AstraZeneca Here’s your chance. Utilising cutting-edge technologies, such as single B-cell RNA sequencing combined with in silico molecular modelling of antigen:antibody interactions, this project aims to understand how to drive immune responses to produce better antigen specific antibodies. If this is your passion, don’t miss out on this role.A detailed understanding of the process of B-cell affinity maturation has been hindered by the inability to track the behaviour of individual B-cells upon interaction with antigens. For this post-doctoral project, we hypothesise that the process of affinity maturation is echoed in the B-cell transcriptomic profile, and, therefore, we aim to investigate this through single B-cell RNA sequence analysis of both the B-cell receptor repertoire and the B-cell transcriptome. This data will be combined with in silico modelling of antigen:antibody interactions in order to generate a better understanding of the B-cell affinity maturation process to enable us to generate higher affinity target specific antibodies.Essential Education and Experience: