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Clinical Pharmacometrician

Job LocationRoyston
EducationNot Mentioned
SalaryCompetitive salary
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Clinical Pharmacometrician Location: Cambridge, UK Salary: CompetitiveAt AstraZeneca when we see an opportunity for change we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.Do you have experience in the clinical pharmacometric aspects of drug development Are you conversant with model-informed drug development If you’re a high-calibre Pharmacometrician, this is an opportunity to join AstraZeneca as a Clinical Pharmacometrician in Cambridge, UK, supporting small and large molecule projects within the Oncology disease area.A world-leading pharmaceutical company, we focus on discovering and developing medicines that make a real difference to millions of patients. We are continuing to grow our state-of-the-art Clinical Pharmacology and Quantitative Pharmacology (CPQP) Department globally. You’ll thrive in an environment that inspires innovation, encourages multidisciplinary team-working and collaboration with academia, and rewards original scientific thinking.Main duties and responsibilitiesWorking closely with physicians, clinical pharmacology scientists and statisticians, you’ll be responsible for population PK, PKPD, exposure-response, disease modelling and simulation (M&S) efforts to support the design and interpretation of clinical studies, influence key decisions in the early and late clinical development and support regulatory submissions of our Oncology medicines. The work includes integration and analysis of pharmacokinetic, biomarker and clinical endpoint data within and across studies, compounds and development stages. Input into trial designs using simulations and efficient modeling statistics is an important focus area for us. In collaboration with clinical pharmacology scientists, you’ll represent CPQP on projects and contribute to the clinical pharmacology and pharmacometric strategy. You will communicate your findings to other scientists within AstraZeneca with the opportunity and expectation to present externally and publish in peer reviewed journals.Essential requirementsYou must have:

  • PhD degree preferred or equivalent (M.Sc./Pharm.D.) with relevant experience required
  • Relevant regulatory experience (written)
  • Training and experience with population PK and statistical software (e.g. NonMem, R, Stan, Winbugs, SAS, Monolix , Phoenix, WinNonlin)
  • Demonstrated expertise in pharmacometrics, including PK, PKPD and/or statistics
  • Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling).
  • Expert knowledge of pharmacokinetics and Model-Informed Drug Development
  • Demonstrated broad translational and clinical development expertise and experience exemplified by significant drug development experience, with emphasis on Clinical Pharmacometrics
  • Demonstrated ability to identify, develop and execute Pharmacometrics activities at a project level
  • Good oral and written communication skills
  • Good knowledge of global regulatory, compliance, processes, standards and issues specific to clinical pharmacology
  • You’ll need real passion for your subject, along with a high level of integrity, plus demonstrated ability to work in multi-disciplinary global teams.Desirable requirementsYou will ideally have:
  • Scientific expertise demonstrated by scientific publishing in the field of clinical pharmacometrics
  • Early or late phase clinical development experience/awareness
  • Knowledge in pharmacology, drug targets and Oncology
  • Closing date: 10th August 2020.AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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