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Process Engineer Chemical Development

Astra Zeneca
Job LocationMacclesfield
EducationNot Mentioned
SalaryCompetitive salary
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Process Engineer - Chemical DevelopmentMacclesfield At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life-changing medicines. Every single day, we make a difference by delivering potentially life-changing medicines to millions of people globally and by leading breakthrough science that promises to transform the treatment of disease. Our purpose is ambitious and so is our approach. Becoming a more agile and creative company means building a dynamic, inspiring culture where we celebrate diverse, bold thinking and act with a sense of urgency. We are curious, creative, and open to new ideas and ways of working.We work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity, even in the most difficult Situations because we are committed to doing the right thing.We believe in the potential of our people and you’ll develop beyond what you thought possible! We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.We have an exciting opportunity for a Process Engineer to join our Chemical Development team.In Chemical Development, we believe that nothing is impossible, and we are compelled to push the boundaries of science to deliver medicines to our patients. We combine people’s technical knowledge and understanding, with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients (APIs) of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop.In this role you will specialise in the development, optimisation and scale up of New Modality API processes. Current new modalities in the Chemical Development portfolio include oligonucleotides (naked and conjugated), synthetic peptides and dendrimers.As a Process Engineer on New Modality projects, you will work closely with fellow chemical engineers, chemists, analysts, colleagues from different departments and external contacts to develop, optimise and scale-up chemical processes to manufacture new modality APIs robustly and sustainably. Key Responsibilities:

  • Provide engineering expertise to develop and optimise new modality manufacturing processes to successfully and robustly deliver drug substances. This includes laboratory experimentation, modelling and simulation and assessment of the results obtained
  • Investigate innovative technologies to improve yield, cycle times and sustainability of new modality processes and develop these technologies for implementation at manufacturing scale
  • Carry out scale-up and manufacturability assessments of processes to ensure right first-time scale-up, technical transfer and future viability
  • Work closely with internal Supply Chain colleagues and external Contract Manufacturing Organisations (CMOs), providing engineering input into process development, technical discussions and the accommodation of processes into manufacturing facilities to deliver drug substance for clinical trials
  • Drive learning from manufactures and deliver process improvements which can be implemented in future manufacture
  • Support problem solving when issues arise during external manufactures
  • Collaborate with colleagues in Drug Product Development to understand the requirements for the physical properties of drug substances and develop processes providing these properties
  • Participate in the overall drug substance control strategy, ensuring processes are fully understood and will robustly deliver the required drug substance quality
  • Provide input into regulatory submissions including section authoring and document reviews
  • Drive technical excellence and implementation of new ways of working by developing industrial and academic networks, and contribute to the wider New Modalities scientific community
  • Mentor and supervise other colleagues where required
    • Essential requirements:
  • A degree and/or PhD in Chemical Engineering, or a relevant discipline (or equivalent experience)
  • Relevant knowledge/experience of new modality projects, such as oligonucleotide and/or peptide experience, understanding of relevant unit operations and their dependency on scale and equipment. (Unit operations include: solid phase synthesis, preparative chromatography, tangential flow filtration, thin film evaporation and isolation of amorphous materials)
  • Strong collaborative skills and experience in working with different skillsets (e.g. with chemists, analysts and physical properties specialists)
  • Understanding of the requirements, principles and application of Safety, Health and Environment (SHE) regulations and Good Manufacturing Practice (GMP)
  • Strong communication and influencing skills
    • Preferred Requirements:
  • Experience working in the Pharmaceutical or Fine Chemicals Industry
  • Experience of chemical process development, scale up and/or transfer of processes between manufacturing facilities
  • Ability to use modelling software (e.g. Aspen, DynoChem, Computational Fluid Dynamics) to support process understanding
  • Experience of working with CMOs
  • Experience in leading technical projects, or acting as a lead process engineer on projects
    • Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering ground-breaking methods and bringing unexpected teams together. Interested Come and join our journey!Please include a current CV and cover letter in your application.AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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