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Drug Discovery Senior Scientist

Job LocationCambridgeshire
EducationNot Mentioned
SalarySalary negotiable
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Wren Therapeutics Limited is seeking to appoint a talented scientist for its rapidly growing research division. The appointee will assist in running a busy experimental laboratory and perform routine cell culture and in vitro cell-based assays that are associated with pre-clinical candidate selection and validation of new drugs.Client DetailsWren therapeutics, founded in 2016, is a spin-off company from the University of Cambridge (UK) and Lund University(Sweden).The company is based at the University of Cambridge, in the recently opened Chemistry of Health Centre, and is focused on drug discovery and development for protein misfolding diseases. Alzheimers and Parkinsons diseases are widely known examples of this group for medical disorders, but others include type -2 diabetes and many rare diseases amongst the more than 50 in total.Protein misfolding diseases are one of the most critical global healthcare challenges of the 21st century. However, current strategies- in particular those driven by traditional drug discovery and biological approaches- have proven, at least to date, to be ineffective,On January 22nd, 2019, Wren announced an 18 million Series A financing from an international syndicate led by The Baupost Group with participation from Life Force Capital and a number of private investors.DescriptionKey Responsibilities:

  • Assist in running a busy experimental laboratory, including the growth and maintenance of different cell lines, working with stem cells, and keeping record of experimental work
  • Perform a range of cell assays to test toxicity of protein aggregates and the ability of potential inhibitors to reduce such toxicity in cells
  • Develop new assays, including high throughput experiments for drug screening
  • Use appropriate software packages effectively for data analysis
  • Write and contribute to publications or disseminate research findings using other media, including making presentations at conferences or exhibiting work at academic or industry conferences
  • Communicate complex ideas and concepts to those with limited knowledge and understanding as well as to peers
  • Mentor colleagues with less experience
  • ProfileKey Skills and Qualifications:
  • PhD degree in biology, biochemistry, or a related discipline, at a leading academic institution
  • Experience with handling immortalized and primary cell lines
  • Experience with human stem cell derived-neurons is valuable
  • Extensive experience in cell biology assays using a range of techniques, such as absorbance, fluorescence, luminescence, confocal microscopy, flow cytometry and qPCR.
  • Experience in high-throughput toxicity assays for drug screening is valuable
  • Experience in bioinformatic tools, software analysis
  • Knowledge of biological biosafety levels.
  • Evidence of ability to work independently and lead, organise and participate in collaborative research projects
  • Experience in assisting to run a busy cell biology laboratory (i.e. purchasing, maintenance of equipment related to cell biology).
  • Job Offer22 days holidaysOption to buy/sell holidayPrivate HealthcareGroup Income ProtectionGroup Life AssuranceCompetitive workplace pension schemeUnum LifeWorks- Well-beingUnum Life Works- Perks

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