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| Job Location | Cambridge |
| Education | Not Mentioned |
| Salary | £35,000 - £45,000 per annum |
| Industry | Not Mentioned |
| Functional Area | Not Mentioned |
| Job Type | Contract, full-time |
Project: Improving the sensitivity and accuracy of ligand detection and placement into X-ray and cryo-EM mapsAstex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery (FBDD) platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and BalversaTM partnered with Janssen). Astex continues to grow and focuses on Oncology and Neurological Disorders.The Astex Sustaining Innovation Postdoctoral research program has a track record of performing cutting-edge research and development and is a key element of our excellent scientific culture. During your SI Postdoc project you will be exposed to a multi-disciplinary pharma environment. You’ll benefit from our internal training seminars that will enhance your understanding of the drug discovery process. As part of your career development, you will have the opportunity to present your work within the company and at external meetings and you’ll be expected to publish your findings in high-impact journals.A postdoctoral position is available within the Molecular Sciences department to develop automated ligand fitting guided by experimental electron density / electrostatic potential maps. The project will focus on locating, sharpening and classifying unmodelled regions of density, determining the identity of the binder using density shape and other physical properties derived from the surroundings, and subsequently fitting the molecule taking potential interactions with the environment into account. Any new methods will be benchmarked using publicly available datasets and a proprietary Astex data repository containing over 10000 protein-ligand complexes.Candidate Requirements;