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| Job Location | Cambridge |
| Education | Not Mentioned |
| Salary | £35,000 - £45,000 per annum |
| Industry | Not Mentioned |
| Functional Area | Not Mentioned |
| Job Type | Contract, full-time |
Project:Development of AI technologies to facilitate and automate the structure-based optimisation of fragment hits into leads.Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery (FBDD) platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and BalversaTM partnered with Janssen). Astex continues to grow and focuses on Oncology and Neurological Disorders.Astex’s sustaining innovation Postdoctoral research program aims to maintain and further enhance the Company’s excellent scientific culture by fostering basic research in areas of interest to the drug discovery field, whilst working with scientists in both the biotech sector and with academic.As part of the Sustaining Innovation program, Astex now has an opening for a postdoctoral scientist to work on Artificial Intelligence (AI) methods to aid the structure-based fragment-to-lead optimisation process. The successful candidate would join Astex’s computational chemistry and informatics team, which has extensive expertise in developing structure-based design applications, and will be working alongside medicinal chemists, modellers and structural biologists.AI technology is now widespread in society and has started to find applications in the drug discovery space. An area that has had very little attention is the application of AI in an interactive design context, i.e. the use of AI to evaluate and propose changes to existing scaffolds within the context of a protein binding site. The proposed SI postdoc project aims to look at exactly this application of AI. This is a challenging, cutting edge application of AI that is right in Astex’s field of expertise: developing fragment hits into potent leads. A unique feature of this project is that the successful candidate will have full access to Astex’s database of many 1000s of X-ray structures of fragment-protein complexes.Candidate Requirements;