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Senior Scientist: Cell Based Screening Custom Arrayed

Talentspa
Job LocationCambridge
EducationNot Mentioned
SalaryCompetitive salary
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent, full-time

Job Description

Senior Scientist: Cell Based Screening (Custom Arrayed)Location: CambridgeSalary: CompetitiveAbout the Company:Horizon Discovery is an innovative and rapidly growing life sciences services and reagents company focused on providing a diverse portfolio of inspired cell solutions to pharmaceutical, biotechnology, CRO, diagnostic, clinical laboratory, and academic areas across the globe. Through a world-class assay development and screening platform, Horizon Discovery empowers researchers with the results they need to understand the biology behind genomics, oncology, and immunology. We act as a discovery partner for leading pharma and biotech companies worldwide, accelerating the speed of new therapeutics to the market.In order to enable the continued expansion of our state-of-the-art CRISPR-Cas9 and compound Screening Platforms, we have a great opportunity for two ambitious Senior Scientists, highly experienced in complex cell-based screening, to join our Custom Arrayed Screening Services group.As a Senior Scientist in the custom services team you be responsible designing, developing and delivering novel and innovative complex screening assays in cell-based model systems using CRISPR, RNAi or compound-based technologies and high-throughput screening/automation techniques for fee-paying commercial clients. The successful candidates will have a strong R&D background, be highly experienced in assay development and show good commercial awareness.This is a lab-based role and candidates should be highly self-motivated, able to work to tight timelines and be comfortable working under pressure in an environment with shifting priorities.Senior Scientist Responsibilities:

  • Collaborate, plan and perform CRISPR-Cas9, RNAi and compound screening experiments independently with minimal supervision, in accordance with project aims and specifications.
  • Confidently engage with customers on a scientific level to:
  • Understand their scientific needs
  • Design research programmes that answer their key scientific questions
  • Report on milestone delivery and project status
  • Discuss results and next steps
  • Analyse and interpret experimental data; identify and solve experimental problems
  • Prepare high quality client facing data packages and reports, clearly disseminating the results of that research to the team and relevant stakeholders
  • Maintain an awareness of current and emerging techniques/technologies and apply these to each project
  • Partner closely with product management and project management to ensure smooth delivery of services and results
  • Follow and give instructions, comply with company policies and be an effective team member in supporting the research and development functions in Horizon
    • Senior Scientist Requirements:
  • Relevant work experience after PhD (or equivalent experience)
  • A strong background in a relevant disease area and the ability to quickly learn new techniques and areas of biology
  • Experience of arrayed high-throughput assays, use of automation and LIMS as well as experience in handling large datasets including data QC, analysis, generating relevant graphical representations etc
  • Extensive experience of mammalian cell culture, excellent aseptic technique and performing various cell based assays, such as those commonly employed at Horizon ( experience and enthusiasm for assay development
  • Excellent interpersonal and communication skills, both written and verbal.
  • Flexibility, adaptability and ability to work in a matrix-managed environment
  • Excellent planning/organizational skills with a careful and meticulous nature and exceptional attention to detail
  • Ability to perform multiple tasks simultaneously, keep accurate records, follow and give instructions, and comply with company policies
  • Proven ability to disseminate research results e.g. in reports, presentations and peer reviewed journal publications
    • Desirable:
  • Experience of working in an industrial setting
  • Experience with High Content Imaging
  • Experience with complex cell models such as organoids, iPSCs or primary cells
  • Experience with transfection, transduction and techniques to modulate gene expression in mammalian cell models e.g. CRISPR-Cas9, siRNA, shRNA etc
  • Some knowledge of programmatic aspects of research (cost, resources and schedule)
  • Experience in scripting, for example in R or Python
    • If you think that you are suitable for this Senior Scientist role, please apply now!Horizon Delivers inspired solutions that harness the power of the cell. We are global leaders in cell engineering. Our vision is to unlock the power of the cell, and we are increasing our focus on customers every day. Our unique tools and services are used by our customers to provide valuable insights and applications in - research, drug discovery, molecular diagnostics and biomanufacturing.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

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