Naukrijobs UK
Register
London Jobs
Manchester Jobs
Liverpool Jobs
Nottingham Jobs
Birmingham Jobs
Cambridge Jobs
Glasgow Jobs
Bristol Jobs
Wales Jobs
Oil & Gas Jobs
Banking Jobs
Construction Jobs
Top Management Jobs
IT - Software Jobs
Medical Healthcare Jobs
Purchase / Logistics Jobs
Sales
Ajax Jobs
Designing Jobs
ASP .NET Jobs
Java Jobs
MySQL Jobs
Sap hr Jobs
Software Testing Jobs
Html Jobs
IT Jobs
Logistics Jobs
Customer Service Jobs
Airport Jobs
Banking Jobs
Driver Jobs
Part Time Jobs
Civil Engineering Jobs
Accountant Jobs
Safety Officer Jobs
Nursing Jobs
Civil Engineering Jobs
Hospitality Jobs
Part Time Jobs
Security Jobs
Finance Jobs
Marketing Jobs
Shipping Jobs
Real Estate Jobs
Telecom Jobs

RNA Synthesis Senior Scientist

Hays Specialist Recruitment Limited
Job LocationCambridge
EducationNot Mentioned
Salary45,000 - 60,000 per annum
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypePermanent , full-time

Job Description

We are currently seeking an RNA Synthesis Senior Scientist who will join the Cell Culture & Fermentation Sciences team, a team who are responsible for generating recombinant proteins and novel drug modalities to support internal projects at all stages ofDrug Discovery. The team is responsible for the development of exciting new technologies around mRNA/saRNA, viral vectors and rapid protein expression. The successful candidate will play a key role in the further development and improvement of the latest technologies around the production of novel drug modalities like mRNA and saRNA. There will also be opportunities to contribute to other activities such asthe rapid protein expression and scale-up of recombinant proteins using in-house protein expression technologies as well as other novel drug modalities like AAV/viral vectors. Main Responsibilities:

  • Key contributor to the establishment of a high yielding and high-quality scalable mRNA and saRNA production process
  • Develop robust and scalable in vitro transcription process using DoE principles
  • Hands-on contribution to drug design, screening, optimisation, and scale-up efforts for mRNA/saRNA synthesis
  • Hands-on contribution to generation of high-quality preclinical grade mRNA/saRNA material
  • Leading and contribution to technology development activities around the production of novel drug modalities including new generation RNA synthesis processes
  • Supporting laboratory activities within Cell Culture and Fermentation Sciences including rapid recombinant protein production using transient expression systems and contribution to general laboratory troubleshooting
  • Maintain high quality documentation of results in electronic lab notebooks and draft protocols as required.
  • Generate clear and appropriate reports according to project requirements.
  • Ensure work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g., Good Laboratory Practice (GLP)
Qualifications & Experience:
  • BSc/ PhD in Life Science - Biotechnology, Molecular Biology, Biochemistry, Chemical Engineering or other relevant scientific field, with proven relevant experience in the Life Science industry
  • Biopharmaceutical process development including mRNA/saRNA synthesis
  • Optimising in vitro transcription and RNA production technologies.
  • Molecular/cell biology techniques such as PCR, plasmid production/processing, DNA template design, DNA sequencing data analysis and alignment
  • Bioreactor process scale up and scale down models for nucleic acid synthesis
  • Knowledge of enzyme kinetics and standard analytical techniques for macromolecules
Desirables:
  • Mammalian cell culture and recombinant protein expression from mammalian cells in an industrial and/or academic environment
  • Experience in using transient expression platforms for rapid recombinant protein expression
  • Experience in stable expression systems
  • Experience working with bioreactor systems for mammalian cell culture
If you think you match the skills listed above and are looking for a new challenge in the Biotech industry, then please apply with your CV or call Thomas Nash on +44 (0) for a completely confidential chat about your situation.

APPLY NOW

RNA Synthesis Senior Scientist Related Jobs

© 2019 Naukrijobs All Rights Reserved