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Research Associate Discovery Pharmacology

Job LocationCambridge
EducationNot Mentioned
Salary£75.00 - £85.00 per day
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypeContract, full-time

Job Description

Pharma, biotech, pharma jobs, bicycle, drug discovery, scientist, senior scientist Your new company My client was founded in 2009 to convert innovative Bicycles into transformative medicines for life-altering diseases. Their proprietary phage display screening platform is based on novel science first conceived in the laboratory of Sir Greg Winter, winner of the Nobel Prize in Chemistry in 2018 for pioneering work in phage display. We are a transatlantic company, headquartered in the vibrant life science cluster of Cambridge, U.K. Your new role This is an exciting new opportunity for a skilled and motivated Research Associate to join our Discovery Pharmacology team on a 12-month fixed-term contract. The successful applicant will have prior hands-on experience of assay development and screening in an industry setting. Direct experience of mammalian cell culture and development, optimisation and validation of cell-based technologies such as reporter gene assays and flow cytometry is highly desirable. You will enjoy a varied and rewarding role, developing and running a range of in vitro assays to screen and characterise novel peptides identified by the Bicycles platform. You will be joining an established and expanding biology team, supporting multiple programs across a diverse range of therapeutic areas. You will be predominantly lab-based and responsible for generating key affinity, selectivity and mechanism of action data by running biochemical and cell-based, binding and functional assays with the aim of identifying and characterising high affinity Bicyclic peptides. Key Responsibilities

  • Maintain mammalian cell cultures using aseptic technique, providing assay-ready cells to the wider team
  • Use existing validated biochemical, biophysical and cell-based assays to characterise Bicycles within a matrixed drug discovery team to agreed timelines
  • You will be expected to analyse and critically interpret assay data, to characterise the pharmacology and mechanism of action of Bicycles
  • Problem-solve, troubleshoot and identify potential next steps, improvements and alternative/novel technologies
  • Record experiments accurately and diligently in electronic lab books and databases
  • Work to existing SOPs and codes of practice
  • Generate reproducible and robust data to drive internal project progression and for inclusion in patents/publications
  • Present the results of independently conducted research effectively in oral or written form, to internal teams, including conclusions and possible next steps
  • Key Skills and Competencies
  • BSc in a relevant field plus prior experience from at least one role in a pharmaceutical or biotech setting
  • Previous experience in mammalian cell culture and performing cell-based binding and functional assays such as flow cytometry and signalling assays
  • Previous experience across a diverse array of assay platforms (e.g. SPR, fluorescence polarisation, HTRF, AlphaScreen) plus an interest in developing and implementing new technologies
  • Strong team-work and interpersonal skills. Confident and experienced in presenting to senior management
  • Good computing skills in basic MS Office suite software and statistical analysis packages
  • Diligent in documenting work and adherence to needs of data integrity
  • Desirable Capabilities:
  • Experience with small molecule drug discovery projects and a robust understanding of the wider drug discovery process
  • Experience in using data analysis software packages, databases and ELNs e.g. Dotmatics and GraphPad Prism
  • What you need to do nowIf youre interested in this role, click apply now to forward an up-to-date copy of your CV, or call us now.If this job isnt quite right for you but you are looking for a new position, please contact us for a confidential discussion on your career.

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