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Job Location | Cambridge |
Education | Not Mentioned |
Salary | Competitive salary |
Industry | Not Mentioned |
Functional Area | Not Mentioned |
Job Type | Permanent, full-time |
At AstraZeneca we believe in the potential of our people and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us. Our scientific research and development is afforded the utmost respect so we give our people the same. We do everything we can to make sure each AstraZeneca person has everything they need to stretch themselves and see what they can achieve.Discovery Sciences is a multi-faceted department which drives early drug discovery across AstraZeneca’s global Innovative Medicines and Early Development (IMED) portfolio. Mechanistic Biology & Profiling (part of Discovery Sciences), is a global, multidisciplinary department responsible for mechanism-of-action studies and compound profiling for efficacy and pre-clinical safety in support of the Oncology, Cardiovascular, Renal & Metabolism (CVRM), Respiratory, Inflammation & Autoimmunity (RIA), and Neuroscience portfolios.As the Principal Scientist, Enzymology, within the Mechanistic Biology & Profiling Group in Cambridge, UK, you will pursue world-class medicines in new ways, combining our peoples extraordinary skills with those of people from all over the globe. Main Duties and Responsibilities: Reporting directly to the Global Head of the Mechanistic Biology & Profiling Department you will set the vision and drive our strategy for the integration of mechanistic enzymology into projects to characterise our drug targets and their interactions with ligands, from generation of early understanding of the underlying biology through to aiding clinical dose prediction.You will lead our mission to provide early, impactful mechanistic enzymology insight to projects across the IMEDs, influencing globally through matrix teams to combine a variety of approaches including in vitro enzymology, pharmacology, and quantitative cell biology. You will be a recognized scientific leader, able to represent the discipline across a broad range of therapeutic projects and global initiatives within Discovery Sciences and IMEDs, and also externally. You will drive scientific and technical innovation, including through external collaboration and partnership. You will also be a key member of the Global Mechanistic Biology & Profiling Leadership Team, participating in setting and maintaining the strategic direction and scientific quality of the department. Essential Requirements: